Management of orbital lymphangioma using intralesional injection of OK-432

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Management of orbital lymphangioma using intralesional injection of OK-432.

AIM To treat orbital lymphangioma with an intralesional injection of OK-432 (group A Streptococcus pyogenes of human origin). METHOD A 14 year old boy had a right orbital cystic lymphangioma. The visual acuity in the eye was 20/28. In an initial treatment, 0.02 mg of OK-432, was injected into the tumour after aspiration of the fluid contents, but no effect was seen. The second treatment was p...

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[Unsuccessful treatment with OK-432 picibanil for orbital lymphangioma].

INTRODUCTION Lymphangioma is a malformation of the lymphatic system. The classic approach is surgery. We report a case of orbital lymphangioma in a girl who was given OK-432 to avoid surgery and its complications. DISCUSSION OK-432 is a lyophilized mixture of group A Streptococcus pyogenes which produces a fibrosis limited to the lesion with a high cure rate. The main advantages are the easy ...

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Intralesional Injection of OK-432 in Cystic Hygroma.

BACKGROUND Lymphangiomas are congenital malformations of the lymphatic system with characteristic dilated endothelium-lined spaces. It is vulnerability to infection or chemical irritants cause spontaneous reduction in size and in some cases complete resolution. Intralesional injection of OK-432 or Picibanil (lyophilized incubation mixture of Group A Streptococcus pyogenes of human origin) is sl...

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[OK-432 therapy for lymphangioma in children].

OBJECTIVE To report the experience with OK-432 therapy for lymphangioma in children. METHODS Retrospective study of 19 children with lymphangioma treated with OK-432 in Ribeirão Preto, state of São Paulo, Brazil, between 1999 and 2003. RESULTS All patients presented response to OK-432, 12 had total shrinkage and seven had partial shrinkage varying from 50 to 80%. Patients had fever after in...

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Cavernous lymphangioma of the leg in children treated by the injection of OK-432 after resection.

We describe the treatment of three boys with cavernous lymphangioma of the legs. The suggested guidelines for treatment are extensive surgical resection, although complete resection is usually impossible, and approximately two weeks after the operation aspiration of serous fluid which has accumulated at the operation site, followed by injection of OK-432 (Picibanil). There was pyrexia and local...

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ژورنال

عنوان ژورنال: British Journal of Ophthalmology

سال: 2000

ISSN: 0007-1161

DOI: 10.1136/bjo.84.6.614